医学新闻听力NPR News:特殊感恩节Kidney Donors Meet Recipients
摘要: 约翰霍普金斯医院成功实施了全球首例五对肾脏配对移植手术,通过一位非定向捐赠者(Honey Rothstein)的善举触发连锁配对捐赠,使五位原本无法与亲属匹配的患者成功接受肾移植。
- 此次五对肾脏移植是全球首例“五重配对肾移植”,依赖复杂的交叉匹配机制完成。
- 一位匿名利他捐赠者(Honey Rothstein)的加入启动了整个捐赠链,使原本不兼容的供受体对得以重新配对。
- 所有10台手术在同一天、同一医疗团队下同步进行,以确保每位捐赠者的付出都能换来其亲人或指定对象的移植机会。
- 参与者术后恢复良好,摆脱了长期透析的束缚,重获生活质量。
- 该案例展示了活体肾捐赠配对网络在解决免疫不兼容问题上的巨大潜力。
小白老师说:约翰霍普金斯的医生们成功地为五位患者进行肾移植手术,感恩节到了,NPR采访了肾脏的捐赠者和受赠者们,还有了不起的医生们,快来听一下他们的肺腑之言。
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Earlier this week at John’s Hopkins Hospital in Baltimore, five kidney transplant patients came face to face with their organ donors for the first time. The five donors and five recipients were recovering, after taking part in what doctors called the first-ever quintuple kidney transplant. NPR’s Luke Burbank reports.
This is “Day to Day,” I’m Alex Chadwick . Today, Thanksgiving, family gatherings all across the country. But few will be as emotionally charged as a reunion earlier this week at Johns Hopkins hospital in Baltimore, five kidney transplant patients actually met their organ donors for the first time. The five donors and five recipients were all recovering after taking part in the first ever quintuple kidney transplant. NPR’s Luke Burbank has more.
Sheila Thornton spent the last four years hook-up to a machine. Thanks to a condition you have probably never even heard of by its technique name. Focal segmental glomerulo sclerosis , in other words late stage kidney failure. During those four years Thornton was on the list for a transplant but a suitable match never appeared which is where the machines came in. First she was going to a Maryland hospital three days a week, five hours a day where she was hooked up for dialysis. Eventually though even that stopped working.
With different problems, with infections, then the grafts that they put in, I switched to what they call peritoneal dialysis and you, I did it at home, ah, nine hours every night. But it’s still that it’s not the same as having a kidney.
As Gerald Loevner of Sarasota, Florida knows all too well. After a series of open heart surgeries he suffered kidney failure too. His wife Sandy says it affects every aspect of your life.
It’s amazing what you can’t have including water; your foods have to be limited. We try to keep Gerald to three and a half cups of liquid a day, that includes anything that can turn to liquid, like jello.
Gerald Loevner was also on the transplant list and Sandy his wife was happy to give him her kidney. But they were not an ideal match. A fairly common situation says Doctor Robert Montgomery who directs the Johns Hopkins Transplant Center.
We had four, err, different couples that came to us and each had a willing donor but there was an incompatibility between the donor and the recipient.
Things were not looking great for these people or for Sheila Thornton who by now was just hoping to get a kidney from a cadaver also not the ideal situation.
And that’s where Honey Rothstein came in.
That’s right. Honey Rothstein, a 48 years old IRS employee from West Virginia who decided 2 Thanksgivings ago, that she wanted to donate a kidney to someone who needed it in honor of her late daughter.
Sometimes you just have to do what, what feels good in your heart. I mean, you do what’s right in your heart and you think, you know, maybe I can, I can do something good for somebody.
Rothstein probably had no idea though just how much good she was about to do. You see, Honey Rothstein’s kidney fit like the missing piece to a puzzle, it matched a woman named Christian Jantzi of Maine that meant Jantzi 's adoptive mother Florence could give her kidney to a better match. A guy named Jeorge Brooks. In turn, Jeorge Brooks’s wife Sharon was able to donate her kidney to a more ideal candidate, a fellow name Gary Persell, whose wife Leslie then gave her kidney to Gerald Loevner, the guy from Sarasota, which meant his wife Sandy could now give her kidney to, you guessed it, Sheila Thornton.
So Mrs. Thonrto so far how is the Sandy Loevner’s kidney doing? How’s it feeling?
Oh wow. Ha… It is wonderful. It is wonderful.
Does that make you kind of proud, Sandy, that you were, you know you were taking good care that kidney for 63 years, and now someone else is getting to use it?
It does, I got to tell you that lady is used to a lot of water, that’s all I can tell you. We live in Florida where it’s hot and that kidney has been well exercised.
All ten surgeries were performed on the same afternoon last week by Doctor Montgomery and his Johns Hopkin team. It took 12 surgeons, six operating rooms and a staff of over 100, but in the end they’d managed a quintuple kidney transplant which by all accounts is some kind of new record. Records aside , doctor Montgomery says there is a legitimate reason all the surgeries needed to happen at once.
To remove the variable of , you know, something happening that would hold-up some of the operation and you know someone might donate a kidney and their loved one not get one.
Doctor Montgomery says it was only after he’d finished all the surgeries as he looked at a complicated diagram of who got which kidney that it hit him.
I mean that, I will never forget that, that moment when I actually had the realization of what we had accomplished. It was, ah, it was very cool.
So cool, in fact, that Doctor Montgomery says that one moment made all those years of medical school, all those sleep deprived hours as a resident worth it. And for the patients all of whom are recovering well, the record-breaking procedure means freedom from dialysis machines, freedom to drink more than 3.5 cups liquid a day and a lifelong bond with someone who until last week was a complete stranger. Luke Burbank, NPR news.
Thank you, Loevner, I’ll be in touch, Sheila, thank you. Thank you for making Thanksgiving special.
Thank you.
Bye, Honey.
Vocabulary
quintuple 五的, 五倍的, 五部分组成的
sclerosis 硬化症, 硬化, 硬结
glomerulosclerosis n.肾血管球硬化症
dialysis 透析, 分离,血液透析
peritoneal 腹膜的
cadaver 死尸, 尸体
IRS Internal Revenue Service 美国国税局
by all accounts 据大家所说
常见问题
什么是五重肾移植(quintuple kidney transplant)?
五重肾移植指五对活体供者与受者通过交叉配对,在同一天完成十台手术,实现五名患者同时获得匹配肾脏的复杂移植过程。
为什么需要所有手术同时进行?
为避免中途变故(如某位供者退出或受者状况恶化),确保每位捐赠者的肾脏都能换来其关联受者的移植机会,必须同步完成全部手术。
非定向捐赠者(如Honey Rothstein)在移植链中起什么作用?
非定向捐赠者不指定受者,其肾脏可启动‘捐赠链’,通过配对系统帮助多对不兼容的供受体重新组合,扩大移植可能性。
患者为何难以找到匹配的亲属捐赠者?
即使亲属愿意捐赠,也可能因血型或组织相容性不匹配而无法直接移植,需借助配对交换机制寻找合适组合。
参考资料
NPR报道:Kidney Donors Meet Recipients After Quintuple Transplant
原始音频新闻来源,由NPR记者Luke Burbank报道
约翰霍普金斯医院器官移植中心
↗手术实施机构,由Robert Montgomery医生领导