VOA慢速英语 | 美国科学家研发出无痛疫苗接种法
摘要: 美国科学家研发出一种无痛流感疫苗接种方法,采用可溶解微针贴片替代传统注射,临床试验证明其安全性和有效性与常规针剂相当。
- 新型流感疫苗贴片使用可溶解微针,贴敷数分钟后即可完成接种,无需冷藏且无锐器废弃物。
- 临床试验显示该贴片在18至49岁人群中与传统注射疫苗具有相似的免疫保护效果。
- 约70%的受试者更偏好贴片方式,尤其适用于对针头恐惧的人群。
- 该技术由埃默里大学医学院主导测试,成果发表于《柳叶刀》期刊。
- 制造商Global Center for Medical Innovation正探索将该平台用于麻疹、腮腺炎和风疹等其他疫苗。
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New Vaccination Method Protects Against Influenza
Most people think of influenza as a common health problem – not a serious condition.
Yet an influenza infection can be deadly, especially in older adults, young children and people with weak or failing health.
Every year, less than half of all adult Americans who should have a flu vaccine actually get one.
The vaccine is injected into the muscle of the upper arm. The injection is painful. It can leave redness on the skin and cause swelling, temporarily enlarging the area.
In the United States, flu season usually begins in late autumn and continues until spring.
Now, scientists have developed a treatment that may soon take the pain out of flu vaccines. And, they hope it will increase the percentage of Americans getting flu shots.
Nadine Rouphael is a professor of infectious diseases at Emory University School of Medicine in Atlanta, Georgia. She was the lead investigator for clinical testing of the influenza skin patch.
Rouphael explained that the patch has very small needles that contain the flu vaccine. She said the needles completely melt into the skin and do not leave any sharp waste afterward.
Patients wear the patch for just a few minutes. Then, the material can be thrown away.
The clinical tests took place in June 2015 and involved 100 patients. They were from 18 to 49 years old. None had received a flu vaccine during the most recent influenza season.
The patients were divided into four groups.

Health care providers or patients put on the influenza patches. Some of the patients also received the vaccine by injection. The fourth group was given a placebo, or harmless substance.
Whether the patch was put on the skin by a health care provider or by a patient, Rouphael says it was as safe and effective as the common needle injection. There were few harmful effects, including a small amount of redness and swelling, which lasted a few days.
The findings were reported in The Lancet.
The investigators wrote in their report that, six months after the vaccination, both the common needle and patch methods offered similar protection.
Nadine Rouphael says the patients who used the patch liked it.
“We do have a lot of people that are typically scared of needles and they’re more prone or were more excited about being part of this clinical trial so they could try the microneedle instead.”
Rouphael says 70 percent of those who used the patch liked it more than an injection.
The patch does not need to be kept in cool place. So Rouphael says it could be sold in stores or mailed to patients. The fact that it is painless, she notes, means more people will probably get vaccinated against the seasonal flu virus.
The Global Center for Medical Innovation manufactures the patch. The company is also investigating using the technology for other vaccines, including for measles, mumps and rubella.
I’m Alice Bryant.
常见问题
这种无痛疫苗贴片是如何工作的?
贴片含有微小的可溶解针头,内含流感疫苗,贴在皮肤上几分钟后针头完全溶解,释放疫苗,无需注射。
贴片疫苗是否和传统注射一样有效?
是的,临床试验表明,贴片在接种六个月后提供的保护效果与传统肌肉注射相当。
这种贴片需要冷藏保存吗?
不需要,该贴片在常温下稳定,便于储存、运输,甚至可通过邮寄分发或在普通商店销售。
谁参与了这项研究?
由埃默里大学医学院传染病学教授Nadine Rouphael领导,在2015年对100名18至49岁未接种当季流感疫苗的成年人进行了临床测试。
参考资料
The Lancet: Influenza vaccine delivery via microneedle patch
研究结果发表于国际权威医学期刊《柳叶刀》,但具体文章链接需根据实际出版信息确认。
Emory University School of Medicine - Nadine Rouphael研究团队
临床试验由埃默里大学医学院主导,详细信息可查询该校官网或相关学术发布。
Global Center for Medical Innovation
该机构负责制造微针贴片,并正在拓展其在其他疫苗中的应用。