一家医院同时进行五例肾移植手术
摘要: 2019年,约翰霍普金斯医院成功完成全球首例五对肾移植配对交换手术,通过一位非定向活体捐赠者的加入,促成五位患者与五位捐赠者之间的连锁匹配,实现同时进行的五例肾移植。
- 该手术采用配对交换(paired exchange)机制,解决多对捐赠-受赠者之间血型或组织不兼容的问题。
- 一名匿名利他捐赠者(Honey Rothstein)的加入成为关键,触发连锁反应,使五对患者-捐赠者成功匹配。
- 所有十台手术在同一天、同一医疗团队下完成,动用12名外科医生、6间手术室和上百名医护人员。
- 此类多米诺式肾移植可显著提高活体捐赠效率,减少患者等待时间和对透析的依赖。
- 该案例体现了器官移植协作网络在提升移植成功率和公平性方面的潜力。

小白老师说:2019 年3月14日是第14个世界肾脏日,今年主题是“Kidney health for everyone everywhere”。今天和大家分享一则NPR新闻,关于约翰霍普金斯同时进行五例肾移植手术的报道,五位器官受赠者的家属互为器官捐赠者。
This is “Day to Day,” I’m Alex Chadwick. Today, Thanksgiving, family gatherings all across the country. But few will be as emotionally charged as a reunion(重聚) earlier this week at Johns Hopkins hospital in Baltimore, five kidney transplant patients actually met their organ donors(器官捐赠者) for the first time. The five donors and five recipients(受赠者) were all recovering after taking part in the first ever quintuple kidney transplant. NPR’s Luke Burbank has more.
Sheila Thornton spent the last four years hook-up to a machine. Thanks to a condition you have probably never even heard of by its technique name. Focal segmental glomerulo sclerosis(局灶性节段性肾小球硬化症), in other words late stage kidney failure.
During those four years Thornton was on the list for a transplant but a suitable match never appeared which is where the machines came in. First she was going to a Maryland hospital three days a week, five hours a day where she was hooked up for dialysis(透析). Eventually though even that stopped working.

With different problems, with infections, then the grafts that they put in, I switched to what they call peritoneal(腹膜的) dialysis and you, I did it at home, ah, nine hours every night. But it’s still that it’s not the same as having a kidney.
As Gerald Loevner of Sarasota, Florida knows all too well. After a series of open heart surgeries he suffered kidney failure(肾衰竭) too. His wife Sandy says it affects every aspect of your life.
It’s amazing what you can’t have including water; your foods have to be limited. We try to keep Gerald to three and a half cups of liquid a day, that includes anything that can turn to liquid, like jello(果冻).
Gerald Loevner was also on the transplant list and Sandy his wife was happy to give him her kidney. But they were not an ideal match. A fairly common situation says Doctor Robert Montgomery who directs the Johns Hopkins Transplant Center.
We had four, err, different couples that came to us and each had a willing donor but there was an incompatibility(不匹配)between the donor and the recipient.

Things were not looking great for these people or for Sheila Thornton who by now was just hoping to get a kidney from a cadaver(尸体) also not the ideal situation.
And that’s where Honey Rothstein came in.
That’s right. Honey Rothstein, a 48-year-old IRS(美国国税局) employee from West Virginia who decided two Thanksgivings ago, that she wanted to donate a kidney to someone who needed it in honor of her late daughter.
Sometimes you just have to do what, what feels good in your heart. I mean, you do what’s right in your heart and you think, you know, maybe I can, I can do something good for somebody.
Rothstein probably had no idea though just how much good she was about to do. You see, Honey Rothstein’s kidney fit like the missing piece to a puzzle(拼图), it matched a woman named Christian Jantzi of Maine that meant Jantzi 's adoptive mother Florence could give her kidney to a better match.
A guy named Jeorge Brooks. In turn, Jeorge Brooks’s wife Sharon was able to donate her kidney to a more ideal candidate, a fellow name Gary Persell, whose wife Leslie then gave her kidney to Gerald Loevner, the guy from Sarasota, which meant his wife Sandy could now give her kidney to, you guessed it, Sheila Thornton.
So Mrs. Thonrto so far how is the Sandy Loevner’s kidney doing? How’s it feeling?
Oh wow. Ha… It is wonderful! It is wonderful!
Does that make you kind of proud, Sandy, that you were, you know you were taking good care that kidney for 63 years, and now someone else is getting to use it?
It does, I got to tell you that lady is used to a lot of water, that’s all I can tell you. We live in Florida where it’s hot and that kidney has been well exercised.
All ten surgeries were performed on the same afternoon last week by Doctor Montgomery and his Johns Hopkin team. It took tweleve surgeons, six operating rooms and a staff of over 100, but in the end they’d managed a quintuple kidney transplant which by all accounts(据说) is some kind of new record. Records aside, doctor Montgomery says there is a legitimate reason all the surgeries needed to happen at once.

To remove the variable of, you know, something happening that would hold-up some of the operation and you know someone might donate a kidney and their loved one not get one.
Doctor Montgomery says it was only after he’d finished all the surgeries as he looked at a complicated diagram of who got which kidney that it hit him.
I mean that, I will never forget that, that moment when I actually had the realization of what we had accomplished. It was, ah, it was very cool.
So cool, in fact, that Doctor Montgomery says that one moment made all those years of medical school, all those sleep deprived hours as a resident worth it. And for the patients all of whom are recovering well, the record-breaking procedure means freedom from dialysis machines, freedom to drink more than 3.5 cups liquid a day and a lifelong bond with someone who until last week was a complete stranger. Luke Burbank, NPR news.
Thank you, Loevner, I’ll be in touch, Sheila, thank you. Thank you for making Thanksgiving special.
Thank you.
Bye, Honey.
敲黑板
- quintuple 五的, 五倍的, 五部分组成的
- glomerulosclerosis 局灶性节段性肾小球硬化症
- dialysis 透析, 分离,血液透析
- incompatibility 不匹配
- peritoneal 腹膜的
- cadaver 死尸, 尸体
- IRS(Internal Revenue Service)美国国税局
- by all accounts 据大家所说
其实世界上还有一例六个肾脏同时移植的手术,英文报道链接**▼**
世界肾脏日的官网链接:https://www.worldkidneyday.org/
更多内容可点击下方蓝字回顾▼
点击阅读原文购买新版魔法书▼****
常见问题
什么是配对肾移植(paired kidney exchange)?
配对肾移植是指当捐赠者与指定受赠者不兼容时,通过与其他不兼容配对交换捐赠者,实现相互匹配的移植方式。
为什么需要同时进行所有移植手术?
为避免中途有人退出或出现意外导致部分患者失去移植机会,所有手术必须同步完成以确保公平和安全。
非定向捐赠者(利他捐赠者)在移植链中起什么作用?
非定向捐赠者不指定受赠人,其捐赠可启动一条移植链,帮助多个原本无法匹配的配对完成交换。
这种五连环移植是否创下了世界纪录?
据报道,这是当时全球首例五对同步肾移植配对交换手术;但后续已有六例同步移植的案例报道。